Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway

• Published in: IUBMB life Vol. 71; no. 7; p. 1041
• Main Authors: Alekhya Sita, Gadamsetty Jaya, Gowthami, Motati, Srikanth, Gadiparthi, Krishna, M Murali, Rama Sireesha, Kokkiligadda, Sajjarao, Mounika, Nagarjuna, Kandru, Nagarjuna, Mukkamulla, Chinnaboina, Gopala Krishna, Mishra, Anurag, SreeHarsha, Nagaraja
• Format: Journal Article
• Language: English
• Published: England 01.07.2019
• Subjects: Animals; Antioxidant Response Elements - genetics; Antioxidants - pharmacology; Benzhydryl Compounds - toxicity; Biomarkers - metabolism; Cytokines - metabolism; Free Radical Scavengers - toxicity; Gene Expression Regulation - drug effects; Heme Oxygenase (Decyclizing) - genetics; Heme Oxygenase (Decyclizing) - metabolism; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Kidney Diseases - chemically induced; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Lipid Peroxidation - drug effects; Luteolin - pharmacology; Male; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Oxidative Stress - drug effects; Phenols - toxicity; Protective Agents - pharmacology; Rats; Rats, Wistar; Signal Transduction - drug effects; anti-inflammatory; luteolin; antioxidant; bisphenol A; nephrotoxicity

For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory pr...