Development and validation of a method for the determination of buprenorphine and norbuprenorphine in breast milk by gas chromatography-mass spectrometry

• Published in: Biomedical chromatography Vol. 26; no. 3; pp. 358 - 362
• Main Authors: Nikolaou, Panagiota, Papoutsis, Ioannis, Athanaselis, Sotirios, Pistos, Constantinos, Dona, Artemis, Spiliopoulou, Chara
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2012
• Subjects: breast milk; buprenorphine; Buprenorphine - analogs & derivatives; Buprenorphine - analysis; Calibration; Gas Chromatography-Mass Spectrometry - methods; GC/MS; Humans; Limit of Detection; Milk, Human - chemistry; nor-buprenorphine; Reference Standards; Reproducibility of Results; Solid Phase Extraction

ABSTRACT Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP‐d4 was...