Development and validation of a method for the determination of buprenorphine and norbuprenorphine in breast milk by gas chromatography-mass spectrometry
ABSTRACT Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP‐d4 was...
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Published in | Biomedical chromatography Vol. 26; no. 3; pp. 358 - 362 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Chichester, UK
John Wiley & Sons, Ltd
01.03.2012
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Abstract | ABSTRACT
Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP‐d4 was used as internal standard. The sample preparation includes combination of protein precipitation with solid‐phase extraction and derivatization (acetylation). The absolute recovery for both analytes was found to be higher than 87.3%. The limits of detection and quantification were 0.07 and 0.20 µg/L, respectively. The calibration curves were linear within the dynamic range 0.20–20.0 µg/L, with a correlation coefficient higher than 0.996. Intra‐ and inter‐day accuracies were ranged from −7.06 to 4.50 and from −5.88 to 7.00%, respectively, while intra‐ and inter‐day precision were less than 5.7 and 6.1%. The analytes were found to be stable in breast milk at 4°C for one week, at −20°C for one month, and after three freeze–thaw cycles. The method can be used for the determination of BUP and nor‐BUP in breast milk of BUP‐maintained mothers, in order to calculate the amount of drug that could pass to the newborn via breast milk and to avoid toxic consequences of breastfeeding. Copyright © 2011 John Wiley & Sons, Ltd. |
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AbstractList | Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP‐d4 was used as internal standard. The sample preparation includes combination of protein precipitation with solid‐phase extraction and derivatization (acetylation). The absolute recovery for both analytes was found to be higher than 87.3%. The limits of detection and quantification were 0.07 and 0.20 µg/L, respectively. The calibration curves were linear within the dynamic range 0.20–20.0 µg/L, with a correlation coefficient higher than 0.996. Intra‐ and inter‐day accuracies were ranged from −7.06 to 4.50 and from −5.88 to 7.00%, respectively, while intra‐ and inter‐day precision were less than 5.7 and 6.1%. The analytes were found to be stable in breast milk at 4°C for one week, at −20°C for one month, and after three freeze–thaw cycles. The method can be used for the determination of BUP and nor‐BUP in breast milk of BUP‐maintained mothers, in order to calculate the amount of drug that could pass to the newborn via breast milk and to avoid toxic consequences of breastfeeding. Copyright © 2011 John Wiley & Sons, Ltd. ABSTRACT Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP‐d4 was used as internal standard. The sample preparation includes combination of protein precipitation with solid‐phase extraction and derivatization (acetylation). The absolute recovery for both analytes was found to be higher than 87.3%. The limits of detection and quantification were 0.07 and 0.20 µg/L, respectively. The calibration curves were linear within the dynamic range 0.20–20.0 µg/L, with a correlation coefficient higher than 0.996. Intra‐ and inter‐day accuracies were ranged from −7.06 to 4.50 and from −5.88 to 7.00%, respectively, while intra‐ and inter‐day precision were less than 5.7 and 6.1%. The analytes were found to be stable in breast milk at 4°C for one week, at −20°C for one month, and after three freeze–thaw cycles. The method can be used for the determination of BUP and nor‐BUP in breast milk of BUP‐maintained mothers, in order to calculate the amount of drug that could pass to the newborn via breast milk and to avoid toxic consequences of breastfeeding. Copyright © 2011 John Wiley & Sons, Ltd. Buprenorphine (BUP) is used for the maintenance of opioid-addicted pregnant women. Because BUP and its main metabolite nor-BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP-d4 was used as internal standard. The sample preparation includes combination of protein precipitation with solid-phase extraction and derivatization (acetylation). The absolute recovery for both analytes was found to be higher than 87.3%. The limits of detection and quantification were 0.07 and 0.20 µg/L, respectively. The calibration curves were linear within the dynamic range 0.20-20.0 µg/L, with a correlation coefficient higher than 0.996. Intra- and inter-day accuracies were ranged from -7.06 to 4.50 and from -5.88 to 7.00%, respectively, while intra- and inter-day precision were less than 5.7 and 6.1%. The analytes were found to be stable in breast milk at 4 °C for one week, at -20 °C for one month, and after three freeze-thaw cycles. The method can be used for the determination of BUP and nor-BUP in breast milk of BUP-maintained mothers, in order to calculate the amount of drug that could pass to the newborn via breast milk and to avoid toxic consequences of breastfeeding. |
Author | Pistos, Constantinos Athanaselis, Sotirios Nikolaou, Panagiota Papoutsis, Ioannis Spiliopoulou, Chara Dona, Artemis |
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Cites_doi | 10.1016/0376-8716(85)90067-5 10.1177/089033440001600206 10.1097/00005053-199306000-00004 10.1542/peds.2008-0571 10.1007/s00216-009-2706-z 10.1542/peds.2005-1561 10.1177/089033449701300312 10.2165/00003088-200544070-00001 10.1038/clpt.1994.71 10.1016/j.forsciint.2004.03.024 10.1093/jat/31.7.377 10.1097/01.ftd.0000164612.83932.be 10.1046/j.0306-5251.2001.01506.x 10.1177/0890334403261027 10.1046/j.1360-0443.2003.00551.x 10.1046/j.1365-2125.1997.t01-1-00624.x 10.1001/jama.1965.03090080008002 10.1177/0890334408328295 10.1542/peds.111.6.1429 |
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References | Kayemba-Kay's S and Laclyde JP. Buprenorphine withdrawal syndrome in newborns: a report of 13 cases. Addiction 2003; 98(11): 1599-1604. Lindemalm S, Nydert P, Svensson JO, Stahle L and Sarman I. Transfer of buprenorphine into breast milk and calculation of an infant drug dose. Journal of Human Lactation 2009; 25(2): 199-205. Wojnar-Horton RE, Kristensen JH, Yapp P, Ilett KF, Dusci LJ and Hackett LP. Methadone distribution and excretion into breast milk of clients in a methadone maintenance programme. British Journal of Clinical Pharmacology 1997; 44(6): 543-547. Dole VP and Nyswander M. A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride. Journal of the American Medical Association 1965; 193: 80-84. Kraft WK, Gibson E, Dysart K, Damle VS, LaRusso JL, Greenspan JS, Moody DE, Kaltenbach K and Ehrlich ME. Sublingual buprenorphine for treatment of the neonatal abstinence syndrome: a randomized trial. Pediatrics 2008; 122(3): 601-607. Grimm D, Pauly E, Pöschl J, Linderkamp O and Skopp G. Buprenorphine and norbuprenorphine concentrations in human breast milk samples determined by liquid chromatography-tandem mass spectrometry. Therapeutic Drug Monitoring 2005; 27: 526-530. Kosten TR, Schottenfeld R, Ziedonis D and Falcioni J. Buprenorphine versus methadone maintenance for opioid dependence. Journal of Nervous Mental Disease 1993; 181(6): 358-364. McCarthy JJ and Posey BL. Methadone levels in human milk. Journal of Human Lactation 2000; 16: 115-120. Walsh SL, Preston KL, Stitzer ML, Cone EJ and Bigelow GE. Clinical pharmacology of buprenorphine: ceiling effects at high doses. Clinical Pharmacology and Therapeutics 1994; 55: 569-580. Abdel-Latif ME, Pinner J, Clews S, Cooke F, Lui K and Oei J. Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent mothers. Pediatrics 2006; 117(6): 1163-1169. Begg EJ, Malpas TJ, Hackett LP and Ilett KF. Distribution of R- and S-methadone into human milk during multiple, medium to high oral dosing. British Journal of Clinical Pharmacology 2001; 52: 681-685. Concheiro-Guisan M, Shakleya DM and Huestis MA. Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in human placenta by liquid chromatography mass spectrometry. Analytical and Bioanalytical Chemistry 2009; 394: 513-522. Wang G, Vincent M, Rodrigues W, Agrawal A, Moore C, Barhate R, Abolencia E, Coulter C, Soares J, Zheng YF, Taylor C and Morjana N. Development and GC-MS validation of a highly sensitive recombinant G6PDH-based homogenous immunoassay for the detection of buprenorphine and norbuprenorphine in urine. Journal of Analytical Toxicology 2007; 31: 377-382. Jansson LM, Velez M and Harrow C. Methadone maintenance and lactation: a review of the literature and current management guidelines. Journal of Human Lactation 2004; 20(1): 62-71. George S, George C and Chauhan M. The development and application of a rapid gas chromatography-mass spectrometry method to monitor buprenorphine withdrawal protocols. Forensic Science International 2004; 143: 121-125. Elkader A and Sproule B. Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence. Clinical Pharmacokinetics 2005; 44(7): 661-680. Lewis JW. Buprenorphine. Drug Alcohol Dependence 1985; 14: 363-372. Philipp BL, Merewood A and O'Brein S. Methadone and breastfeeding: new horizons. Pediatrics 2003; 111: 1429-1430. Kobayashi K, Yamamoto T, Chiba K, Tani M, Shimada N, Ishizaki T and Kuroiwa Y. Human buprenorphine N-dealkylation is catalysed by cytochrome P450 3A4. Drug Metabolism and Disposition 1998; 26: 818-821. Geraghty B, Graham EA, Logan B and Weiss EL. Methadone levels in breast milk. Journal of Human Lactation 1997; 13: 227-230. 1998; 26 2004; 143 2009; 25 2004; 20 2000; 16 2001 1997; 44 1997; 13 1994; 55 1965; 193 2005 2009; 394 1993; 181 2007; 31 2005; 27 2008; 122 2006; 117 2005; 44 2003; 111 2001; 52 2003; 98 1985; 14 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_3_1 e_1_2_8_2_1 Kobayashi K (e_1_2_8_14_1) 1998; 26 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_10_1 e_1_2_8_21_1 e_1_2_8_11_1 e_1_2_8_22_1 e_1_2_8_12_1 e_1_2_8_23_1 |
References_xml | – volume: 181 start-page: 358 issue: 6 year: 1993 end-page: 364 article-title: Buprenorphine versus methadone maintenance for opioid dependence publication-title: Journal of Nervous Mental Disease – volume: 143 start-page: 121 year: 2004 end-page: 125 article-title: The development and application of a rapid gas chromatography–mass spectrometry method to monitor buprenorphine withdrawal protocols publication-title: Forensic Science International – volume: 26 start-page: 818 year: 1998 end-page: 821 article-title: Human buprenorphine ‐dealkylation is catalysed by cytochrome P450 3A4 publication-title: Drug Metabolism and Disposition – volume: 122 start-page: 601 issue: 3 year: 2008 end-page: 607 article-title: Sublingual buprenorphine for treatment of the neonatal abstinence syndrome: a randomized trial publication-title: Pediatrics – volume: 193 start-page: 80 year: 1965 end-page: 84 article-title: A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride publication-title: Journal of the American Medical Association – year: 2005 – year: 2001 – volume: 117 start-page: 1163 issue: 6 year: 2006 end-page: 1169 article-title: Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug‐dependent mothers publication-title: Pediatrics – volume: 44 start-page: 543 issue: 6 year: 1997 end-page: 547 article-title: Methadone distribution and excretion into breast milk of clients in a methadone maintenance programme publication-title: British Journal of Clinical Pharmacology – volume: 52 start-page: 681 year: 2001 end-page: 685 article-title: Distribution of ‐ and ‐methadone into human milk during multiple, medium to high oral dosing publication-title: British Journal of Clinical Pharmacology – volume: 16 start-page: 115 year: 2000 end-page: 120 article-title: Methadone levels in human milk publication-title: Journal of Human Lactation – volume: 31 start-page: 377 year: 2007 end-page: 382 article-title: Development and GC‐MS validation of a highly sensitive recombinant G6PDH‐based homogenous immunoassay for the detection of buprenorphine and norbuprenorphine in urine publication-title: Journal of Analytical Toxicology – volume: 14 start-page: 363 year: 1985 end-page: 372 article-title: Buprenorphine publication-title: Drug Alcohol Dependence – volume: 55 start-page: 569 year: 1994 end-page: 580 article-title: Clinical pharmacology of buprenorphine: ceiling effects at high doses publication-title: Clinical Pharmacology and Therapeutics – volume: 394 start-page: 513 year: 2009 end-page: 522 article-title: Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in human placenta by liquid chromatography mass spectrometry publication-title: Analytical and Bioanalytical Chemistry – volume: 27 start-page: 526 year: 2005 end-page: 530 article-title: Buprenorphine and norbuprenorphine concentrations in human breast milk samples determined by liquid chromatography–tandem mass spectrometry publication-title: Therapeutic Drug Monitoring – volume: 20 start-page: 62 issue: 1 year: 2004 end-page: 71 article-title: Methadone maintenance and lactation: a review of the literature and current management guidelines publication-title: Journal of Human Lactation – volume: 98 start-page: 1599 issue: 11 year: 2003 end-page: 1604 article-title: Buprenorphine withdrawal syndrome in newborns: a report of 13 cases publication-title: Addiction – volume: 25 start-page: 199 issue: 2 year: 2009 end-page: 205 article-title: Transfer of buprenorphine into breast milk and calculation of an infant drug dose publication-title: Journal of Human Lactation – volume: 44 start-page: 661 issue: 7 year: 2005 end-page: 680 article-title: Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence publication-title: Clinical Pharmacokinetics – volume: 13 start-page: 227 year: 1997 end-page: 230 article-title: Methadone levels in breast milk publication-title: Journal of Human Lactation – volume: 111 start-page: 1429 year: 2003 end-page: 1430 article-title: Methadone and breastfeeding: new horizons publication-title: Pediatrics – ident: e_1_2_8_17_1 doi: 10.1016/0376-8716(85)90067-5 – ident: e_1_2_8_19_1 doi: 10.1177/089033440001600206 – ident: e_1_2_8_15_1 doi: 10.1097/00005053-199306000-00004 – ident: e_1_2_8_16_1 doi: 10.1542/peds.2008-0571 – ident: e_1_2_8_4_1 doi: 10.1007/s00216-009-2706-z – ident: e_1_2_8_2_1 doi: 10.1542/peds.2005-1561 – ident: e_1_2_8_9_1 doi: 10.1177/089033449701300312 – ident: e_1_2_8_6_1 doi: 10.2165/00003088-200544070-00001 – ident: e_1_2_8_21_1 doi: 10.1038/clpt.1994.71 – ident: e_1_2_8_11_1 – ident: e_1_2_8_8_1 doi: 10.1016/j.forsciint.2004.03.024 – ident: e_1_2_8_22_1 doi: 10.1093/jat/31.7.377 – volume: 26 start-page: 818 year: 1998 ident: e_1_2_8_14_1 article-title: Human buprenorphine N‐dealkylation is catalysed by cytochrome 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Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into... Buprenorphine (BUP) is used for the maintenance of opioid-addicted pregnant women. Because BUP and its main metabolite nor-BUP are excreted into breast milk, a... Buprenorphine (BUP) is used for the maintenance of opioid‐addicted pregnant women. Because BUP and its main metabolite nor‐BUP are excreted into breast milk, a... |
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SubjectTerms | breast milk buprenorphine Buprenorphine - analogs & derivatives Buprenorphine - analysis Calibration Gas Chromatography-Mass Spectrometry - methods GC/MS Humans Limit of Detection Milk, Human - chemistry nor-buprenorphine Reference Standards Reproducibility of Results Solid Phase Extraction |
Title | Development and validation of a method for the determination of buprenorphine and norbuprenorphine in breast milk by gas chromatography-mass spectrometry |
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