Anion exchanger1 (AE1/SLC4A1) function is impaired in red blood cells from prediabetic subjects: Potential benefits of finger lime (Citrus australasica, Faustrime cultivar) juice extract

• Published in: Cell biochemistry and function Vol. 42; no. 6; pp. e4105 - n/a
• Main Authors: Remigante, Alessia, Spinelli, Sara, Gambardella, Lucrezia, Straface, Elisabetta, Cafeo, Giovanna, Russo, Marina, Caruso, Daniele, Dugo, Paola, Dossena, Silvia, Marino, Angela, Morabito, Rossana
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2024
• Subjects: Adult; Anion exchange; Anion Exchange Protein 1, Erythrocyte - metabolism; anion exchanger 1 (SLC4A1); Anion exchanging; Antioxidants; Antioxidants - chemistry; Antioxidants - metabolism; Antioxidants - pharmacology; Bioactive compounds; Biological activity; Biomarkers; Cardiovascular diseases; Catalase; Cellular structure; Citrus - chemistry; Citrus australasica; Citrus fruits; Condition monitoring; Cultivars; Diabetes mellitus; Dietary supplements; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - metabolism; Female; Fruit and Vegetable Juices - analysis; Functional foods & nutraceuticals; Glutathione; glycation; Glycosylation; Hemoglobin; Homeostasis; Humans; Hyperglycemia; Juices; Lipid peroxidation; Lipids; Male; Methemoglobin; Middle Aged; Molecular modelling; Oxidation; Oxidation resistance; Oxidative stress; Oxidative Stress - drug effects; Peroxidation; Plant Extracts - chemistry; Plant Extracts - pharmacology; Prediabetic State - drug therapy; Prediabetic State - metabolism; Prevention; red blood cells; Spectrin; Structure-function relationships; Superoxide dismutase; glycation; red blood cells; anion exchanger 1 (SLC4A1); hyperglycemia; oxidative stress

Prediabetes is a risk state that defines a high chance of developing diabetes and cardiovascular disease. Oxidative stress mediated by hyperglycemia‐induced production of reactive species could play a crucial role in this context. In the present study, we investigated whether the anion exchange capa...