Differing SAGA module requirements for NCR‐sensitive gene transcription in yeast
Nitrogen catabolite repression (NCR) is a means for yeast to adapt its transcriptome to changing nitrogen sources in its environment. In conditions of derepression (under poor nitrogen conditions, upon rapamycin treatment, or when glutamine production is inhibited), two transcriptional activators of...
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Published in | Yeast (Chichester, England) Vol. 41; no. 4; pp. 207 - 221 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Nitrogen catabolite repression (NCR) is a means for yeast to adapt its transcriptome to changing nitrogen sources in its environment. In conditions of derepression (under poor nitrogen conditions, upon rapamycin treatment, or when glutamine production is inhibited), two transcriptional activators of the GATA family are recruited to NCR‐sensitive promoters and activate transcription of NCR‐sensitive genes. Earlier observations have involved the Spt‐Ada‐Gcn5 acetyltransferase (SAGA) chromatin remodeling complex in these transcriptional regulations. In this report, we provide an illustration of the varying NCR‐sensitive responses and question whether differing SAGA recruitment could explain this diversity of responses.
Model for GATA‐ and SAGA (Spt‐Ada‐Gcn5 acetyltransferase)‐dependent expression of DAL5 and GDH2.
Take‐away
The expression of nitrogen catabolite repression (NCR)‐sensitive genes has been analyzed in Spt‐Ada‐Gcn5 acetyltransferase (SAGA) factor mutants in different nitrogen conditions. Varying NCR‐sensitive responses have been noticed and differing SAGA recruitment could explain this diversity of responses. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0749-503X 1097-0061 |
DOI: | 10.1002/yea.3885 |