Synthesis of deuterium labelled acids

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 42; no. 9; pp. 835 - 842
• Main Authors: Kadam, A. J., Desai, U. V., Mane, R. B.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.1999; Wiley
• Subjects: Aliphatic compounds; Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry; Chemistry, Analytical; Chemistry, Medicinal; Exact sciences and technology; Knoevenagel condensation; Life Sciences & Biomedicine; Meldrum's acid; Organic chemistry; Pharmacology & Pharmacy; Physical Sciences; Preparations and properties; Science & Technology; sodium borodeuteride reduction; α-dideuterated; β-monodeuterated and α; β-trideuterated acids; β‐monodeuterated and α,α,β‐trideuterated acids; beta-monodeuterated and alpha,alpha,beta-trideuterated acids; alpha-dideuterated; Knoevenagel condensation; sodium borodeuteride reduction; Meldrum's acid; Deuterium; Furfural; Aliphatic compound; Benzaldehyde; Hydrogen Isotopes; Sodium Tetrahydroborates; Aldehyde; Oxygen heterocycle; Ketone; Carboxylic acid; Benzenic compound; Chemical synthesis; Labelled compound; Acetone

Knoevenagel condensation of Meldrum's acid (1) with benzaldehyde, anisaldehyde, furfural, cinnamaldehyde and acetone gave the corresponding alkylidene derivatives (3) which were reduced with sodium borohydride to yield alkyl Meldrum's acids (4). Reaction of (4) with pyridine‐D2O at high te...