Sustained Release of Nitric Oxide and Cascade Generation of Reactive Nitrogen/Oxygen Species via an Injectable Hydrogel for Tumor Synergistic Therapy

• Published in: Advanced functional materials Vol. 32; no. 36
• Main Authors: Wang, Yaoben, Yang, Xiaowei, Chen, Xiaobin, Wang, Xin, Wang, Yang, Wang, Hancheng, Chen, Zhiyong, Cao, Dinglingge, Yu, Lin, Ding, Jiandong
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.09.2022
• Subjects: Acetic acid; Cancer; Cascade chemical reactions; chemodynamic therapy; Copolymers; Depletion; Glutathione; Hydrogels; Hydrogen peroxide; Hydroxyl radicals; injectable hydrogels; Materials science; Nanoparticles; Nitric oxide; Oxygen; reactive nitrogen species; Sol-gel processes; Sustained release; Tumors

Reactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive oxygen species (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great potential in cancer treatment, yet it is still largely unexploited. Herein, a novel, injectable and NO‐releasing hydrog...