Natural mucosal barriers and COVID-19 in children

• Published in: JCI insight Vol. 6; no. 9
• Main Authors: Pierce, Carl A, Sy, Sharlene, Galen, Benjamin, Goldstein, Doctor Y, Orner, Erika, Keller, Marla J, Herold, Kevan C, Herold, Betsy C
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 10.05.2021; American Society for Clinical investigation
• Subjects: Clinical Medicine; Infectious disease; Infectious disease; Innate immunity

BACKGROUNDCoronavirus disease 2019 (COVID-19) is more benign in children compared with adults for unknown reasons. This contrasts with other respiratory viruses where disease manifestations are often more severe in children. We hypothesize that a more robust early innate immune response to SARS coro...