Right-handed alternating DNA conformation: poly(dA-dT) adopts the same dinucleotide repeat with cesium, tetraalkylammonium, and 3 alpha, 5 beta, 17 beta-dipyrrolidinium steroid dimethiodide cations in aqueous solution

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 78; no. 7; pp. 4063 - 4067
• Main Authors: Patel, D J, Kozlowski, S A, Suggs, J W, Cox, S D
• Format: Journal Article
• Language: English
• Published: United States National Acad Sciences 01.07.1981
• Subjects: Androstenes; Cations; Cesium; DNA; Hydrogen Bonding; Ligands; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Poly dA-dT; Polydeoxyribonucleotides; Quaternary Ammonium Compounds; Stereoisomerism; Steroids, Heterocyclic; Structure-Activity Relationship

We demonstrate that poly(dA-dT) can adopt two conformations in solution, with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands. The synthetic DNA exhibits a dinucleotide repeat conformation on addition of CsF and Me4NCl at molar concentration...