Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA-125-dependent MCEMP1 downregulation

• Published in: IUBMB life Vol. 71; no. 7; p. 956
• Main Authors: Chen, Jian-Xin, Xu, Xiong, Zhang, Sen
• Format: Journal Article
• Language: English
• Published: England 01.07.2019
• Subjects: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Gene Expression Regulation, Neoplastic; Gene Silencing; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; Sepsis - genetics; Sepsis - immunology; Sepsis - metabolism; Sepsis - pathology; immunity; microRNA-125; mast cell expressed membrane protein 1; sepsis; long noncoding RNA NEAT1

Accumulating studies have recognized microRNAs (miRs) and long noncoding RNAs (lncRNAs) as important molecules involved in the mediation of various biological processes, including innate immunity. In this study, we investigated a novel noncoding RNA regulatory circuitry in the immunity during sepsis...