Arg399Gln substitution in XRCC1 as a prognostic and predictive biomarker for prostate cancer: Evidence from 8662 subjects and a structural analysis

• Published in: The journal of gene medicine Vol. 20; no. 10-11; pp. e3053 - n/a
• Main Authors: Noureddini, Mahdi, Mobasseri, Narges, Karimian, Mohammad, Behjati, Mohaddeseh, Nikzad, Hossein
• Format: Journal Article
• Language: English
• Published: England Wiley Periodicals Inc 01.10.2018
• Subjects: Bioinformatics; Biomarkers; Data processing; Gene polymorphism; Gene therapy; Genotyping; in silico analysis; Meta-analysis; Minority & ethnic groups; Polymerase chain reaction; Polymorphism; Prostate cancer; Protein structure; Restriction fragment length polymorphism; Statistical analysis; Structure-function relationships; XRCC1 gene; XRCC1 protein; in silico analysis; meta-analysis; prostate cancer; XRCC1 gene

Background The Arg399Gln polymorphism in the X‐ray repair cross‐complementing group 1 gene (XRCC1) may alter the risk of prostate cancer (PCa). The present study aimed to investigate the association of the XRCC1‐Arg399Gln polymorphism with PCa risk in an Iranian population, as followed by a meta‐ana...