Reactive Oxygen Species–Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies

• Published in: Advanced functional materials Vol. 29; no. 44
• Main Authors: Zhao, Zhihao, Wang, Weiqi, Li, Chenxi, Zhang, Yiqiu, Yu, Tianrong, Wu, Renfei, Zhao, Jiayue, Liu, Zhuang, Liu, Jian, Yu, Haijun
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.11.2019
• Subjects: Antidotes; Biocompatibility; chemodynamic therapy; Depletion; Fenton reaction; Glutathione; Hydrogen peroxide; Hypoxia; Iron oxides; Liposomes; Materials science; Organic chemistry; Photodynamic therapy; tumor hypoxia; tumor microenvironment; Tumors

Tumors have adapted various cellular antidotes and microenvironmental conditions to subsist against photodynamic therapy (PDT) and chemodynamic therapy (CDT). Here, the development of reactive oxygen species (ROS)‐activatable liposomes (RALP) for therapeutic enhancement by simultaneously addressing...