Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor κB and Activator Protein-1: Possible Mechanism for Acceleration of Atherosclerosis by Subclinical Endotoxemia

• Published in: Circulation research Vol. 107; no. 1; pp. 56 - 65
• Main Authors: Wiesner, Philipp, Choi, Soo-Ho, Almazan, Felicidad, Benner, Christopher, Huang, Wendy, Diehl, Cody J., Gonen, Ayelet, Butler, Susan, Witztum, Joseph L., Glass, Christopher K., Miller, Yury I.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 09.07.2010; Lippincott Williams & Wilkins
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Atherosclerosis - etiology; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cell Line; Disease Progression; Drug Administration Schedule; Drug Synergism; Endotoxemia - etiology; Endotoxemia - metabolism; Endotoxemia - pathology; Fundamental and applied biological sciences. Psychology; Inflammation Mediators - administration & dosage; Lipopolysaccharides - administration & dosage; Lipoproteins, LDL - administration & dosage; Macrophage Activation - physiology; Medical sciences; Mice; Mice, Inbred C57BL; NF-kappa B - physiology; Transcription Factor AP-1 - physiology; Vertebrates: cardiovascular system; Cardiovascular disease; Inflammation; Endotoxin; Vascular disease; Lipoprotein LDL; Toxin; Vertebrata; Mammalia; Activator; Atherosclerosis; Lipopolysaccharide; Circulatory system; Transcription factor NFκB; Acceleration; Dose; Endotoxemia; oxidized lipoprotein; Macrophage
• ISSN: 0009-7330; 1524-4571; 1524-4571
• DOI: 10.1161/CIRCRESAHA.110.218420

RATIONALE:Oxidized low-density lipoprotein (LDL) is an important determinant of inflammation in atherosclerotic lesions. It has also been documented that certain chronic infectious diseases, such as periodontitis and chlamydial infection, exacerbate clinical manifestations of atherosclerosis. In add...