Treating LRRK2‐Related Parkinson's Disease by Inhibiting the mTOR Signaling Pathway to Restore Autophagy

• Published in: Advanced functional materials Vol. 31; no. 38
• Main Authors: Cui, Weitong, Yang, Xiao, Chen, Xingyu, Xiao, Dexuan, Zhu, Junyao, Zhang, Mei, Qin, Xin, Ma, Xiaohong, Lin, Yunfeng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.09.2021
• Subjects: Autophagy; Kinases; Leucine; leucine‐rich repeat kinase 2; Materials science; Mutation; Nucleic acids; Parkinson's disease; Signs and symptoms; tetrahedral framework nucleic acid; vitamin B12

Parkinson's disease (PD) is the most common chronic neurodegenerative disease and is characterized by motor dysfunctions. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are a major cause of the neurotoxicity that causes PD. As an inhibitor of LRRK2 activity, vitamin B12 (VB12) is...