Regional anaesthesia and cancer metastases: the implication of local anaesthetics

• Published in: Acta anaesthesiologica Scandinavica Vol. 57; no. 10; pp. 1211 - 1229
• Main Authors: VOTTA-VELIS, E. G., PIEGELER, T., MINSHALL, R. D., AGUIRRE, J., BECK-SCHIMMER, B., SCHWARTZ, D. E., BORGEAT, A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2013; Wiley Subscription Services, Inc
• Subjects: Acute Lung Injury - drug therapy; Anesthesia, Conduction; Anesthetics, Local - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; Cancer; Humans; Inflammation - complications; Medical research; Medical treatment; Neoplasm Metastasis - prevention & control; Neoplastic Cells, Circulating; NF-kappa B - physiology

Clinical and basic science studies have demonstrated the anti‐inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. Regional anaesthesia is associated in some retrospective clinical studies with reduced risk of metasta...