Regional anaesthesia and cancer metastases: the implication of local anaesthetics
Clinical and basic science studies have demonstrated the anti‐inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. Regional anaesthesia is associated in some retrospective clinical studies with reduced risk of metasta...
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| Published in | Acta anaesthesiologica Scandinavica Vol. 57; no. 10; pp. 1211 - 1229 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.11.2013
Wiley Subscription Services, Inc |
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| Abstract | Clinical and basic science studies have demonstrated the anti‐inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. Regional anaesthesia is associated in some retrospective clinical studies with reduced risk of metastasis and increased long‐term survival. The potential beneficial effects of regional anaesthesia have been attributed mainly to the inhibition of the neuroendocrine stress response to surgery and to the reduction in the requirements of volatile anaesthetics and opioids. Because cancer is linked to inflammation and local anaesthetics have anti‐inflammatory effects, these agents may participate in reducing the risk of metastasis, but their mechanism of action is unknown. We demonstrated in vitro that amide local anaesthetics attenuate tumour cell migration as well as signalling pathways enhancing tumour growth and metastasis. This has provided the first evidence of a molecular mechanism by which regional anaesthesia might inhibit or reduce cancer metastases. |
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| AbstractList | Clinical and basic science studies have demonstrated the anti-inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. Regional anaesthesia is associated in some retrospective clinical studies with reduced risk of metastasis and increased long-term survival. The potential beneficial effects of regional anaesthesia have been attributed mainly to the inhibition of the neuroendocrine stress response to surgery and to the reduction in the requirements of volatile anaesthetics and opioids. Because cancer is linked to inflammation and local anaesthetics have anti-inflammatory effects, these agents may participate in reducing the risk of metastasis, but their mechanism of action is unknown. We demonstrated in vitro that amide local anaesthetics attenuate tumour cell migration as well as signalling pathways enhancing tumour growth and metastasis. This has provided the first evidence of a molecular mechanism by which regional anaesthesia might inhibit or reduce cancer metastases. [PUBLICATION ABSTRACT] Clinical and basic science studies have demonstrated the anti-inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. Regional anaesthesia is associated in some retrospective clinical studies with reduced risk of metastasis and increased long-term survival. The potential beneficial effects of regional anaesthesia have been attributed mainly to the inhibition of the neuroendocrine stress response to surgery and to the reduction in the requirements of volatile anaesthetics and opioids. Because cancer is linked to inflammation and local anaesthetics have anti-inflammatory effects, these agents may participate in reducing the risk of metastasis, but their mechanism of action is unknown. We demonstrated in vitro that amide local anaesthetics attenuate tumour cell migration as well as signalling pathways enhancing tumour growth and metastasis. This has provided the first evidence of a molecular mechanism by which regional anaesthesia might inhibit or reduce cancer metastases. |
| Author | AGUIRRE, J. MINSHALL, R. D. BECK-SCHIMMER, B. SCHWARTZ, D. E. BORGEAT, A. VOTTA-VELIS, E. G. PIEGELER, T. |
| Author_xml | – sequence: 1 givenname: E. G. surname: VOTTA-VELIS fullname: VOTTA-VELIS, E. G. organization: Department of Anaesthesiology, University of Illinois at Chicago, Chicago, IL, USA – sequence: 2 givenname: T. surname: PIEGELER fullname: PIEGELER, T. organization: Department of Anaesthesiology, University of Illinois at Chicago, Chicago, IL, USA – sequence: 3 givenname: R. D. surname: MINSHALL fullname: MINSHALL, R. D. organization: Department of Anaesthesiology, University of Illinois at Chicago, Chicago, IL, USA – sequence: 4 givenname: J. surname: AGUIRRE fullname: AGUIRRE, J. organization: Department of Anaesthesiology, Balgrist University Hospital Zurich, Zurich, Switzerland – sequence: 5 givenname: B. surname: BECK-SCHIMMER fullname: BECK-SCHIMMER, B. organization: Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland – sequence: 6 givenname: D. E. surname: SCHWARTZ fullname: SCHWARTZ, D. E. organization: Department of Anaesthesiology, University of Illinois at Chicago, IL, Chicago, USA – sequence: 7 givenname: A. surname: BORGEAT fullname: BORGEAT, A. email: alain.borgeat@balgrist.ch organization: Department of Anaesthesiology, Balgrist University Hospital Zurich, Zurich, Switzerland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24134442$$D View this record in MEDLINE/PubMed |
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| Snippet | Clinical and basic science studies have demonstrated the anti‐inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular... Clinical and basic science studies have demonstrated the anti-inflammatory properties of local anaesthetics. Recent studies have begun to unravel molecular... |
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| SubjectTerms | Acute Lung Injury - drug therapy Anesthesia, Conduction Anesthetics, Local - pharmacology Animals Anti-Inflammatory Agents - pharmacology Cancer Humans Inflammation - complications Medical research Medical treatment Neoplasm Metastasis - prevention & control Neoplastic Cells, Circulating NF-kappa B - physiology |
| Title | Regional anaesthesia and cancer metastases: the implication of local anaesthetics |
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