Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography - Seneca, Nicholas; Finnema, Sjoerd J.; Laszlovszky, István; Kiss, Béla; Horváth, Attila; Pásztor, Gabriella; Kapás, Margó; Gyertyán, István; Farkas, Sándor; Innis, Robert B.; Halldin, Christer; Gulyás, Balázs (Psychopharmacologia, 2011)
Keywords: Animals; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - metabolism; Antipsychotic Agents - pharmacology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; Dose-Response Relationship, Drug; Macaca fascicularis; Medical sciences; Neuropharmacology; Neurosciences; Original Investigation; Pharmacology. Drug treatments; Pharmacology/Toxicology; Piperazines - administration & dosage; Piperazines - metabolism; Piperazines - pharmacology; Positron-Emission Tomography; Protein Binding; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptor, Serotonin, 5-HT1A - metabolism; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - metabolism; Nonhuman primate brain; Serotonin 5-HT; Positron emission tomography (PET); Dopamine D; Cariprazine; Receptor occupancy; Neuroleptic; Psychotropic; Central nervous system; Monkey; Pharmacotherapy; Encephalon; 5-HT1A Serotonine receptor; Primates; Antipsychotic; Biological receptor; Drug; Dopamine; Serotonin; Catecholamine; Vertebrata; Mammalia; Treatment; Animal; Neurotransmitter; Piperazine derivatives; Positron emission tomography; Emission tomography