Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis - Beike, Lukas; Wrede, Christoph; Hegermann, Jan; Lopez-Rodriguez, Elena; Kloth, Christina; Gauldie, Jack; Kolb, Martin; Maus, Ulrich A.; Ochs, Matthias; Knudsen, Lars (Laboratory investigation, 2019)
Keywords: 14/28; 14/63; 42/109; 42/44; 631/443/1784; 64/60; 692/699/1785; Abnormalities; Airway Remodeling; Alveolar Epithelial Cells - drug effects; Alveolar Epithelial Cells - ultrastructure; Alveoli; Animals; Collagen; Collapse; Correlation analysis; Deposition; Disease Models, Animal; Extracellular matrix; Female; Fibrils; Fibrosis; Gene transfer; Growth factors; Heterogeneity; Laboratory Medicine; Lung diseases; Lungs; Mechanics; Mechanics (physics); Medicine; Medicine & Public Health; Mice, Inbred C57BL; Pathology; Pulmonary fibrosis; Pulmonary Fibrosis - pathology; Pulmonary Fibrosis - prevention & control; Pulmonary Surfactants - pharmacology; Pulmonary Surfactants - therapeutic use; Respiratory Mechanics; Scanning electron microscopy; Sodium chloride; Stereology; Surface area; Surfactants; Trachea; Transforming growth factor; Transforming Growth Factor beta1; Transforming growth factor-b1; Walls