Utility of zanamivir for chemoprophylaxis of concomitant influenza A and B in a complex continuing care population

• Published in: Infection control and hospital epidemiology Vol. 23; no. 10; p. 604
• Main Authors: Hirji, Z, O'Grady, S, Bonham, J, Mak, M, Takata-Shewchuk, J, Hawkins, K, Gardam, M, Law, L, Mazzulli, T, Conly, J
• Format: Journal Article
• Language: English
• Published: United States 01.10.2002
• Subjects: Aged; Aged, 80 and over; Antiviral Agents - adverse effects; Antiviral Agents - therapeutic use; Comorbidity; Cross Infection - drug therapy; Cross Infection - prevention & control; Cross Infection - virology; Disease Outbreaks - prevention & control; Female; Guanidines; Hospital Bed Capacity, 500 and over; Hospital Units - organization & administration; Hospitals, Urban - organization & administration; Humans; Influenza A virus - isolation & purification; Influenza B virus - isolation & purification; Influenza, Human - drug therapy; Influenza, Human - prevention & control; Influenza, Human - virology; Long-Term Care - organization & administration; Male; Middle Aged; Ontario; Premedication; Pyrans; Rehabilitation Centers - organization & administration; Safety; Sialic Acids - adverse effects; Sialic Acids - therapeutic use; Zanamivir; Ontario

To describe compliance with and the safety and prophylactic efficacy of zanamivir among patients at risk of developing influenza-related complications after exposure to both influenza A and B viruses. Nonrandomized trial using both historical and contemporaneous controls from ward populations within...