All-trans-retinoic acid modulates expression levels of thyroglobulin and cytokines in a new human poorly differentiated papillary thyroid carcinoma cell line, KTC-1

• Published in: The journal of clinical endocrinology and metabolism Vol. 85; no. 8; pp. 2889 - 2896
• Main Authors: KUREBAYASHI, J, TANAKA, K, OTSUKI, T, MORIYA, T, KUNISUE, H, UNO, M, SONOO, H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.08.2000
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Carcinoma, Papillary - genetics; Carcinoma, Papillary - pathology; Carcinoma, Papillary - ultrastructure; Cell Differentiation; Cell Division; Chemotherapy; Cytokines - genetics; DNA-Binding Proteins - genetics; Endocrinopathies; Gene Expression Regulation, Neoplastic - drug effects; Genes, p53; Growth Inhibitors - genetics; Humans; Interleukin-6 - genetics; Leukemia Inhibitory Factor; Lymphokines - genetics; Malignant tumors; Medical sciences; Mice; Mice, Nude; Nuclear Proteins - genetics; Paired Box Transcription Factors; PAX8 Transcription Factor; Pharmacology. Drug treatments; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Thyroglobulin - genetics; Thyroid Gland - metabolism; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Thyroid Neoplasms - ultrastructure; Thyroid Nuclear Factor 1; Thyroid. Thyroid axis (diseases); Trans-Activators - genetics; Transcription Factors - genetics; Transcription, Genetic; Transplantation, Heterologous; Tretinoin - pharmacology; Tumor Cells, Cultured; Endocrinopathy; Human; Antineoplastic agent; Immunohistochemistry; Papillary carcinoma; Thyroid diseases; Cytokine; Retinoid; Male; Thyroid gland; Malignant tumor; Gene expression; Genetic determinism; In vitro; Biological activity; Pathology; Thyroglobulin; Adult; Molecular biology; Tretinoin

A new human thyroid carcinoma cell line, KTC-1, was established from the malignant pleural effusion of a recurrent thyroid carcinoma patient. Cytogenetic analysis revealed a normal karyotype, and no p53 mutation in exons 5-9 was detected. This cell line is tumorigenic in athymic nude mice. Histologi...