Substance P plays a critical role in synaptic transmission in striatal neurons
Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P knoc...
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| Published in | Biochemical and biophysical research communications Vol. 511; no. 2; pp. 369 - 373 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
02.04.2019
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| Abstract | Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P knockdown in these neurons impaired spontaneous neurotransmitter release and calcium-dependent rapid synaptic neurotransmission. Furthermore, treatment with exogenous substance P completely rescued the synaptic dysfunction phenotype in striatal neurons lacking this neuropeptide. On the other hand, substance P knockdown had no effect on the size of the readily releasable pool of synaptic vesicles, but decreased the probability of presynaptic release of synaptic vesicles in cultured striatal neurons. Treatment with CP96345, a NK1 receptor antagonist, also resulted in synaptic defects in cultured striatal neurons. In summary, we propose substance P is critical for synaptic transmission in striatal neurons.
•Substance P knockdown in striatal neurons impairs spontaneous release.•Diminished rapid synaptic transmission in striatal neurons lacking substance P.•Substance P is critical for the regulation of the probability of presynaptic release in striatal neurons.•NK1 receptors is important for the modulation of synaptic transmission by substance P. |
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| AbstractList | Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P knockdown in these neurons impaired spontaneous neurotransmitter release and calcium-dependent rapid synaptic neurotransmission. Furthermore, treatment with exogenous substance P completely rescued the synaptic dysfunction phenotype in striatal neurons lacking this neuropeptide. On the other hand, substance P knockdown had no effect on the size of the readily releasable pool of synaptic vesicles, but decreased the probability of presynaptic release of synaptic vesicles in cultured striatal neurons. Treatment with CP96345, a NK1 receptor antagonist, also resulted in synaptic defects in cultured striatal neurons. In summary, we propose substance P is critical for synaptic transmission in striatal neurons. Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P knockdown in these neurons impaired spontaneous neurotransmitter release and calcium-dependent rapid synaptic neurotransmission. Furthermore, treatment with exogenous substance P completely rescued the synaptic dysfunction phenotype in striatal neurons lacking this neuropeptide. On the other hand, substance P knockdown had no effect on the size of the readily releasable pool of synaptic vesicles, but decreased the probability of presynaptic release of synaptic vesicles in cultured striatal neurons. Treatment with CP96345, a NK1 receptor antagonist, also resulted in synaptic defects in cultured striatal neurons. In summary, we propose substance P is critical for synaptic transmission in striatal neurons. •Substance P knockdown in striatal neurons impairs spontaneous release.•Diminished rapid synaptic transmission in striatal neurons lacking substance P.•Substance P is critical for the regulation of the probability of presynaptic release in striatal neurons.•NK1 receptors is important for the modulation of synaptic transmission by substance P. |
| Author | He, Zi-Xuan Song, Hui-Fang Zhu, Xiao-Juan Liu, Ting-Yu Yin, Yue-Yue |
| Author_xml | – sequence: 1 givenname: Zi-Xuan surname: He fullname: He, Zi-Xuan email: hezx234@nenu.edu.cn – sequence: 2 givenname: Ting-Yu surname: Liu fullname: Liu, Ting-Yu – sequence: 3 givenname: Yue-Yue surname: Yin fullname: Yin, Yue-Yue – sequence: 4 givenname: Hui-Fang surname: Song fullname: Song, Hui-Fang – sequence: 5 givenname: Xiao-Juan surname: Zhu fullname: Zhu, Xiao-Juan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30803756$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_braincomms_fcaa105 crossref_primary_10_1002_cne_25413 crossref_primary_10_1523_JNEUROSCI_1857_22_2023 crossref_primary_10_1038_s41531_022_00299_7 crossref_primary_10_1007_s00429_023_02688_x crossref_primary_10_3389_fcell_2021_663535 crossref_primary_10_1155_2022_8425640 |
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| Keywords | Striatum NK1 receptor Substance p Synaptic transmission |
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| Snippet | Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found... |
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| SubjectTerms | Animals Cells, Cultured Corpus Striatum - cytology Corpus Striatum - metabolism Mice Neurons - cytology Neurons - metabolism NK1 receptor Presynaptic Terminals - metabolism Striatum Substance p Substance P - metabolism Synaptic Transmission Synaptic Vesicles - metabolism |
| Title | Substance P plays a critical role in synaptic transmission in striatal neurons |
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