The Malignant Brain Tumor Repeats of Human SCML2 Bind to Peptides Containing Monomethylated Lysine

• Published in: Journal of molecular biology Vol. 382; no. 5; pp. 1107 - 1112
• Main Authors: Santiveri, Clara M., Lechtenberg, Bernhard C., Allen, Mark D., Sathyamurthy, Aruna, Jaulent, Agnès M., Freund, Stefan M.V., Bycroft, Mark
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 24.10.2008
• Subjects: Binding Sites; chromatin; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epigenesis, Genetic; epigenetics; Histones - chemistry; Histones - metabolism; Humans; In Vitro Techniques; Kinetics; Ligands; Lysine - analogs & derivatives; Lysine - chemistry; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides - chemistry; Peptides - metabolism; Polycomb-Group Proteins; PRC1; Protein Binding; Protein Conformation; Repetitive Sequences, Amino Acid; transcription; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism; SCML2; transcription; chromatin; PRC1; MBT; epigenetics

SCML2 (sex comb on midleg-like 2) is a constituent of the Polycomb repressive complex 1, a large multiprotein assembly required for the repression of developmental control genes. It contains two MBT (malignant brain tumor) repeats; the MBT is a protein module structurally similar to domains that bin...