Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets

• Published in: Journal of allergy and clinical immunology Vol. 142; no. 5; pp. 1392 - 1402
• Main Authors: McGovern, Alice E., Short, Kirsty R., Kywe Moe, Aung Aung, Mazzone, Stuart B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; Elsevier Limited
• Subjects: Asthma; Central nervous system; Clinical trials; Cough; Cough hypersensitivity syndrome; Defensive behavior; Disease; Human subjects; Hypersensitivity; Inflammation; Information processing; Lungs; Nerve endings; Nervous system; Neurons; Neuropeptides; Patients; Respiratory tract; Rodents; sensitization; sensory; Sensory neurons; Therapeutic applications; vagal; ASIC; TSLP; Cough hypersensitivity syndrome; sensory; inflammation; P2X; sensitization; vagal; HMGB1; VIP; CGRP; CHS

Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. However, inflammatory pathologies can sensitize and activate the neural pathways regulating cough, leading to excessive and nonproductive coughing that serves little prot...