Hemochromatosis mutations in the general population: iron overload progression rate

• Published in: Blood Vol. 103; no. 8; pp. 2914 - 2919
• Main Authors: Andersen, Rolf Værn, Tybjærg-Hansen, Anne, Appleyard, Merete, Birgens, Henrik, Nordestgaard, Børge Grønne
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.04.2004; The Americain Society of Hematology
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cohort Studies; Denmark; Female; Ferritins - blood; Follow-Up Studies; Hemochromatosis - blood; Hemochromatosis - etiology; Hemochromatosis - genetics; Hemochromatosis Protein; Histocompatibility Antigens Class I - genetics; Homozygote; Humans; Iron Overload - blood; Iron Overload - etiology; Iron Overload - genetics; Male; Medical sciences; Membrane Proteins - genetics; Metabolic diseases; Metals (hemochromatosis...); Middle Aged; Mutation; Other metabolic disorders; Transferrin - metabolism; Denmark; Europe; Human; Phenotype; Hemochromatosis; Overload; Metabolic diseases; Genotype; Population; Iron; Mutation; Enzymopathy

The progression rate of iron overload in hereditary hemochromatosis in individuals in the general population is unknown. We therefore examined in the general population iron overload progression rate in C282Y homozygotes. Using a cohort study of the Danish general population, The Copenhagen City Hea...