LC Characterisation of Guaco Medicinal Extracts, Mikania laevigata and M. glomerata, and their Effects on Allergic Pneumonitis

• Published in: Planta medica Vol. 72; no. 8; pp. 679 - 684
• Main Authors: Santos, S.C. dos, Krueger, C.L, Steil, A.A, Kreuger, M.R, Biavatti, M.W, Junior, A.W
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2006
• Subjects: Alveolitis, Extrinsic Allergic - drug therapy; Alveolitis, Extrinsic Allergic - pathology; animal disease models; Animals; asthma; Bronchi - cytology; Bronchi - drug effects; Bronchoalveolar Lavage; chemical constituents of plants; Chromatography, High Pressure Liquid; coumaric acids; coumarins; Disease Models, Animal; Female; high performance liquid chromatography; histopathology; human health; immediate hypersensitivity; medicinal plants; medicinal properties; Mice; Mice, Inbred BALB C; Mikania; Mikania glomerata; Mikania laevigata; Phytotherapy; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves; pneumonia; quantitative analysis; traditional medicine; Brazil

The leaves of guaco (Mikania glomerata and M. laevigata) are widely used for the treatment of asthma and bronchitis. An LC method for the quantification of coumarin and O-coumaric acid in medicinal extracts was developed and validated for linearity, limit of detection, accuracy, precision, as well a...