The interleukin-6 (−174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians

• Published in: Human genetics Vol. 112; no. 4; pp. 409 - 413
• Main Authors: Vozarova, Barbora, Fernández-Real, José-Manuel, Knowler, William C., Gallart, Lluis, Hanson, Robert L., Gruber, Jonathan D., Ricart, Wilfredo, Vendrell, Joan, Richart, Cristóbal, Tataranni, P. Antonio, Wolford, Johanna K.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.04.2003; Berlin Springer Nature B.V; New York, NY
• Subjects: Adult; Aged; Alleles; Allergic diseases; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Case-Control Studies; Cytosine; Development and progression; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; European Continental Ancestry Group - genetics; Female; General aspects; Genetic aspects; Genotype; Guanine; Hispanic Americans - genetics; Humans; Immunopathology; Indians, North American - genetics; Insulin resistance; Interleukin-6 - genetics; Interleukins; Male; Medical sciences; Middle Aged; Native Americans; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic - genetics; Type 2 diabetes; Endocrinopathy; Interleukin 6; Promoter; American; Genetics; Non insulin dependent diabetes; Polymorphism

Chronic low-grade activation of the immune system may play a role in the pathogenesis of type-2 diabetes mellitus (T2DM). Interleukin-6 (IL6), a powerful inducer of hepatic acute phase response, has been implicated in the etiology of insulin resistance and T2DM. Recently, an IL6 promoter polymorphis...