Total-Body Parametric Imaging Using Relative Patlak Plot

• Published in: Journal of Nuclear Medicine Vol. 66; no. 4; pp. 654 - 661
• Main Authors: Li, Siqi, Abdelhafez, Yasser G., Nardo, Lorenzo, Cherry, Simon R., Badawi, Ramsey D., Wang, Guobao
• Format: Journal Article
• Language: English
• Published: United States 01.04.2025
• Subjects: Adult; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted - methods; Male; Middle Aged; Positron-Emission Tomography - methods; Whole Body Imaging - methods; relative Patlak plot; standard clinical scan; total-body PET parametric imaging; self-supervised deep learning; kinetic modeling

The standard Patlak plot, a simple yet efficient model, is widely used to describe irreversible tracer kinetics for dynamic PET imaging. Its widespread application to whole-body parametric imaging remains constrained because of the need for a full-time-course input function (e.g., 1 h). In this pape...