Neutralization of Different Variants of SARS-CoV-2 by a F(ab')2 Preparation from Sera of Horses Immunized with the Viral Receptor Binding Domain

• Published in: Antibodies (Basel) Vol. 12; no. 4; p. 80
• Main Authors: Rodriguez-Nuñez, Mariajosé, Cepeda, Mariana Del Valle, Bello, Carlos, Lopez, Miguel Angel, Sulbaran, Yoneira, Loureiro, Carmen Luisa, Liprandi, Ferdinando, Jaspe, Rossana Celeste, Pujol, Flor Helene, Rangel, Héctor Rafael
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.12.2023
• Subjects: Animals; Antibodies; Antigens; Binding; Cell adhesion; COVID-19; Disease transmission; equine sera; evolution; Genomes; Horses; immune escape; Immunization; Infections; Mutation; Neutralization; Neutralizing; neutralizing antibodies; Pandemics; Proteins; Receptors; Reduction; RNA polymerase; Severe acute respiratory syndrome coronavirus 2; Spike protein; Strains (organisms); Toxicity; Vaccines; variants; Viral diseases; Viruses; United Kingdom > UK; South Africa; COVID-19; neutralizing antibodies; immune escape; evolution; variants; equine sera

The Receptor Binding Domain (RBD) of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, is the functional region of the viral Spike protein (S), which is involved in cell attachment to target cells. The virus has accumulated progressively mutations in its genome, particularly in the RBD re...