Potential for HER-2/neu molecular targeted therapy for invasive bladder carcinoma: Comparative study of immunohistochemistry and fluorescent in situ hybridization

• Published in: Oncology reports Vol. 19; no. 1; pp. 57 - 63
• Main Authors: Matsubara, Hiroyuki, Yamada, Yoshiaki, Naruse, Katsuya, Nakamura, Kogenta, Aoki, Shigeyuki, Taki, Tomohiro, Tobiume, Motoi, Zennami, Kenji, Katsuda, Remi, Honda, Nobuaki
• Format: Journal Article
• Language: English
• Published: Athens S.n. 01.01.2008
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - analysis; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Drug Delivery Systems; Female; Gene Amplification; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lymphatic Metastasis - pathology; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Receptor, ErbB-2 - biosynthesis; Receptor, ErbB-2 - genetics; Tumors; Tumors of the urinary system; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Urinary tract. Prostate gland; Immunohistochemistry; fluorescent in situ hybridization; Urinary system disease; Targeted therapy; In situ; erbB2 Gene; Urinary tract disease; Malignant tumor; Hybridization; Bladder carcinoma; Bladder cancer; Anatomic pathology; Cancerology; Treatment; C-Onc gene; invasive bladder carcinoma; HER-2/neu; Bladder disease; Invasive cancer; molecular targeted therapy; Comparative study; Protooncogene; Cancer

Analysis of HER-2/neu expression in invasive bladder carcinoma was performed in order to evaluate the potential for molecular targeted therapy targeting HER-2. The subjects were 40 patients who were pathologically diagnosed with invasive transitional cell carcinoma of the bladder (pT2 to pT4). A Her...