A review on comparative study of PPI and PAMAM dendrimers

Dendrimers are hyperbranched, monodispersed macromolecules with multivalent functional end groups. Dendrimers have been explored as carrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti tubercular drugs. Although a number of different types of dendrimers containing dif...

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Bibliographic Details
Published inJournal of Nanoparticle Research Vol. 18; no. 6; p. 1
Main Authors Kaur, Daljeet, Jain, Keerti, Mehra, Neelesh Kumar, Kesharwani, Prashant, Jain, Narendra K.
Format Journal Article Book Review
LanguageEnglish
Published Dordrecht Springer Netherlands 01.06.2016
Springer Nature B.V
Subjects
Characterization and Evaluation of Materials
Chemistry and Materials Science
Inorganic Chemistry
Lasers
Materials Science
Nanoparticles
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Review
Dendrimers
Synthesis
Biomedical applications
Toxicity
PPI
Drug delivery
Properties
PAMAM
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Summary:Dendrimers are hyperbranched, monodispersed macromolecules with multivalent functional end groups. Dendrimers have been explored as carrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti tubercular drugs. Although a number of different types of dendrimers containing different core molecules, branching monomers and surface functional groups have been designed till date for drug delivery applications, yet the poly(propyleneimine) (PPI) and poly(amidoamine) (PAMAM) dendrimers have been the most explored dendrimers in this regard. In this review, we have summarized a comparative data on PPI and PAMAM dendrimers particularly relevant to their properties, synthesis, toxicity, biomedical applications and drug delivery attributes.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-016-3423-0