Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects

• Published in: Cardiovascular research Vol. 56; no. 1; pp. 118 - 125
• Main Author: Singh, N
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2002
• Subjects: Administration, Oral; Aged; Aged, 80 and over; Aging - physiology; Area Under Curve; Ascorbic Acid - administration & dosage; Ascorbic Acid - blood; Biological and medical sciences; Bradykinin; Cardiovascular system; Diet, Mediterranean; Dose-Response Relationship, Drug; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Female; Forearm - blood supply; Humans; Injections, Intra-Arterial; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Nitric Oxide Donors; Nitroglycerin; Plethysmography; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Statistics, Nonparametric; Vasodilator Agents; Human; Ascorbic acid; Acute; Exploration; Long term; Endothelium; Vasomotricity; Diet; Hemodynamics; Supplementation; Vascular wall; Elderly; Comparative study

Aging is associated with endothelial dysfunction. We studied the acute and longer-term effects of vitamin C compared to a 'Mediterranean-type' diet on endothelial function in healthy older subjects. Bilateral venous occlusion plethysmography was used to measure forearm blood flow in subjec...