Psychiatric symptoms after therapy with new antiepileptic drugs: Psychopathological and seizure related variables

• Published in: Seizure (London, England) Vol. 9; no. 4; pp. 249 - 254
• Main Authors: Trimble, Michael R., Rüsch, Nicolas, Betts, Tim, Crawford, Pamela M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2000
• Subjects: Adolescent; Adult; affective disorder; Anticonvulsants - adverse effects; depression; Dominance, Cerebral; Dose-Response Relationship, Drug; epilepsy; Epilepsy - complications; Epilepsy - drug therapy; Female; forced normalization; Fructose - adverse effects; Fructose - analogs & derivatives; Humans; Male; Middle Aged; Mood Disorders - chemically induced; Nipecotic Acids - adverse effects; Psychoses, Substance-Induced - etiology; psychosis; Recurrence; Retrospective Studies; tiagabine; topiramate; United Kingdom; vigabatrin; Vigabatrin - adverse effects; epilepsy; forced normalization; affective disorder; vigabatrin; tiagabine; depression; psychosis; topiramate

The purpose of this paper is to understand the association between antiepileptic drugs (AEDs), patient characteristics, changes in seizure pattern and emergent psychiatric disorder, i.e. psychosis or affective disorder. To this end we carried out a retrospective casenote study on 89 patients who dev...