Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

• Published in: Journal of visualized experiments no. 114
• Main Authors: Li, Feng, Snow-Davis, Candace, Du, Chengan, Bondarev, Mikhail L, Saulsbury, Marilyn D, Heyliger, Simone O
• Format: Journal Article
• Language: English
• Published: United States MyJove Corporation 02.08.2016
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Bioengineering; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Hydrogen-Ion Concentration; Micelles; Particle Size; Polymers; Prodrugs

Micelles have been successfully used for the delivery of anticancer drugs. Amphiphilic polymers form core-shell structured micelles in an aqueous environment through self-assembly. The hydrophobic core of micelles functions as a drug reservoir and encapsulates hydrophobic drugs. The hydrophilic shel...