Cardiac ion channel gene mutations in Greek long QT syndrome patients

• Published in: Journal of applied genetics Vol. 51; no. 4; pp. 515 - 518
• Main Authors: Kotta, C -M., Anastasakis, A., Gatzoulis, K., Papagiannis, J., Geleris, P., Stefanadis, C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2010; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Animal Genetics and Genomics; Arrhythmia; Base Sequence; Biomedical and Life Sciences; Cardiovascular diseases; Child; Coronary artery disease; Diagnosis; DNA Mutational Analysis; Female; Genes; Genetic diversity; Genetic screening; Genotyping; Greece; Heart diseases; Human Genetics; Humans; Infant; Ion channels; Life Sciences; Long QT syndrome; Long QT Syndrome - genetics; Male; Microbial Genetics and Genomics; Middle Aged; Molecular Sequence Data; Mutation; Mutation - genetics; Myocardium - metabolism; Myocardium - pathology; Nucleotides; Patients; Plant Genetics and Genomics; Potassium; Potassium Channels - genetics; Short Communication; Single-nucleotide polymorphism; Sodium Channels - genetics; Greece; mutations; sudden cardiac death; long QT syndrome; genetic testing

The long QT syndrome (LQTS) is an inherited cardiac arrhythmia that may lead to sudden death in the absence of structural heart disease. Mutations in the cardiac potassium and sodium channel genes can be found in approximately 70% of patients with a highly probable clinical diagnosis. In this study,...