Cholesterol Binding at the Cholesterol Recognition/Interaction Amino Acid Consensus (CRAC) of the Peripheral-Type Benzodiazepine Receptor and Inhibition of Steroidogenesis by an HIV TAT-CRAC Peptide

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 3; pp. 1267 - 1272
• Main Authors: Li, Hua, Yao, Zhi-xing, Degenhardt, Babett, Teper, Gary, Papadopoulos, Vassilios
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 30.01.2001; National Acad Sciences; The National Academy of Sciences
• Subjects: Amino Acid Sequence; Animals; Binding Sites; Biological Sciences; Cell Line; Cholesterol - metabolism; Cloning, Molecular; Consensus Sequence; CRAC peptide; Gene Products, tat - chemistry; Gene Products, tat - metabolism; HIV - metabolism; Human immunodeficiency virus; Kinetics; Leydig Cells - physiology; Male; Mice; Mitochondria - metabolism; Molecular Sequence Data; PBR protein; Progesterone - metabolism; promegestone; Promegestone - pharmacokinetics; Receptors, GABA-A - chemistry; Receptors, GABA-A - metabolism; Recombinant Proteins - chemistry; Recombinant Proteins - metabolism; tat Gene Products, Human Immunodeficiency Virus; Tritium

We previously defined a cholesterol recognition/interaction amino acid consensus (CRAC; ATVLNYYVWRDNS in the carboxyl terminus of the peripheral-type benzodiazepine receptor (PBR), an outer mitochondrial membrane protein involved in the regulation of cholesterol transport into the mitochondria, the...