Circulating biomarker analyses in a longitudinal cohort of patients with IPF

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 326; no. 3; pp. L303 - L312
• Main Authors: Ebert, Christina, Walsh, Alice M., Sereda, Larisa, Wilson, Carole L., Schafer, Peter H., Fischer, Aryeh, Zhao, Lei, Ramirez-Valle, Francisco, Gordon, David, Schnapp, Lynn M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2024
• Subjects: Antigens, Neoplasm; Biomarkers; CXCL13 protein; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis - pathology; IP-10 protein; Keratin-19; Lung - metabolism; Lung diseases; Matrilysin; Proteins; Pulmonary fibrosis; Tissue inhibitor of metalloproteinase 1; prediction; fibrosis; idiopathic pulmonary fibrosis; biomarkers

In this study, we confirmed protein expression differences in only a subset of predicted biomarkers from IPF and control subjects. Most differentially expressed proteins were predicted to be secreted from lung cells. However, a significant minority of the proteins are not known to be transcriptional...