Comparison of the Single Cell Immune Landscape between Subjects with High Mycobacterium tuberculosis Bacillary Loads during Active Pulmonary Tuberculosis and Household Members with Latent Tuberculosis Infection

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 4; p. 362
• Main Authors: Kamolratanakul, Supitcha, Ariyanon, Wassawon, Udompornpitak, Kanyarat, Bhunyakarnjanarat, Thansita, Leelahavanichkul, Asada, Dhitavat, Jittima, Wilairatana, Polrat, Chancharoenthana, Wiwat
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.02.2024
• Subjects: Antibodies; Asymptomatic; Bacillus; CyTOF; Cytometry; Disease; Flow cytometry; Health care; Households; Humans; Immune system; Infections; latent tuberculosis; Latent Tuberculosis - diagnosis; Latent Tuberculosis - microbiology; Leukocytes, Mononuclear; Lymphocytes T; Mass spectroscopy; Mycobacterium tuberculosis; Natural killer cells; Peripheral blood mononuclear cells; pulmonary; responder; Tuberculosis; Tuberculosis, Pulmonary; United States > US; South San Francisco California; pulmonary; responder; latent tuberculosis; CyTOF; tuberculosis
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells13040362

It is unclear how the immune system controls the transition from latent tuberculosis (TB) infection (LTBI) to active pulmonary infection (PTB). Here, we applied mass spectrometry cytometry time-of-flight (CyTOF) analysis of peripheral blood mononuclear cells to compare the immunological landscapes i...