Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors

• Published in: Bioorganic & medicinal chemistry Vol. 14; no. 4; pp. 1078 - 1088
• Main Authors: Bouissane, L., El Kazzouli, S., Léonce, S., Pfeiffer, B., Rakib, E.M., Khouili, M., Guillaumet, G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.02.2006
• Subjects: Animals; Cell Cycle - drug effects; Cell Line, Tumor; Humans; Indazole; Indazoles - chemical synthesis; Indazoles - chemistry; Indazoles - pharmacology; L1210 murine leukemia cells; Leukemia - pathology; Mice; Molecular Structure; Palladium; Structure-Activity Relationship; Sulfonamide; Sulfonamides - chemical synthesis; Sulfonamides - chemistry; Sulfonamides - pharmacology; Palladium; Sulfonamide; Indazole; L1210 murine leukemia cells

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy- N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an...