Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

Tocopherol derivatives were found to strongly modulate microglial activation induced by lipopolysaccharide. The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydrox...

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Published inBioorganic & medicinal chemistry letters Vol. 14; no. 24; pp. 6023 - 6026
Main Authors Muller, Thierry, Grandbarbe, Luc, Morga, Eleonora, Heuschling, Paul, Luu, Bang
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.12.2004
Elsevier
Subjects
alpha-Tocopherol - chemical synthesis
alpha-Tocopherol - chemistry
alpha-Tocopherol - pharmacology
Animals
Biological and medical sciences
Cell Line
Fatty Alcohols - chemical synthesis
Fatty Alcohols - chemistry
Fatty Alcohols - pharmacology
Free Radicals - antagonists & inhibitors
Free Radicals - metabolism
Immunomodulators
Long chain fatty alkanol
Medical sciences
Mice
Microglia
Microglia - cytology
Microglia - drug effects
Microglia - metabolism
Molecular Structure
Neuroinflammation
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Pharmacology. Drug treatments
Structure-Activity Relationship
Tocopherol
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - biosynthesis
Neuroinflammation
Long chain fatty alkanol
Tocopherol
Microglia
Immunomodulation
Cytokine
Activation
Biological activity
Chroman derivatives
Side chain
Fatty alcohol
Nitric oxide
Modulation
Production
Inhibition
Chemical synthesis
Tumor necrosis factor α
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Summary:Tocopherol derivatives were found to strongly modulate microglial activation induced by lipopolysaccharide. The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain ( n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-α (TNF-α) by lipopolysaccharide (LPS)-activated microglia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.09.078