Ornithine Decarboxylase Polymorphism Modification of Response to Aspirin Treatment for Colorectal Adenoma Prevention

• Published in: JNCI : Journal of the National Cancer Institute Vol. 98; no. 20; pp. 1494 - 1500
• Main Authors: Barry, Elizabeth L. R., Baron, John A., Bhat, Shubha, Grau, Maria V., Burke, Carol A., Sandler, Robert S., Ahnen, Dennis J., Haile, Robert W., O'Brien, Thomas G.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 18.10.2006; Oxford Publishing Limited (England)
• Subjects: Adenoma - enzymology; Adenoma - ethnology; Adenoma - genetics; Adenoma - prevention & control; Adenomatous Polyposis Coli - drug therapy; Aged; Alanine; Anticarcinogenic Agents - therapeutic use; Aspirin; Aspirin - therapeutic use; Biological and medical sciences; Colorectal cancer; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - ethnology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - prevention & control; Continental Population Groups - genetics; Female; Folic Acid - therapeutic use; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Agents - therapeutic use; Gene Frequency; Genetic markers; Genotype; Genotype & phenotype; Glycine; Humans; Hypothesis testing; Male; Medical sciences; Middle Aged; Ornithine Decarboxylase - genetics; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Risk Assessment; Risk factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; United States; North America; America; Prostaglandin-endoperoxide synthase; Chemoprophylaxis; Rectal disease; Genetic variability; Lyases; Acetylsalicylic acid; Anticarcinogen; Epidemiology; Prevention; Cancerology; Carboxy-lyases; Genetics; Intestinal disease; Salicylates; Benign neoplasm; Public health; Human; Enzyme; Enzyme inhibitor; Genotype; Ornithine decarboxylase; Colonic disease; Non steroidal antiinflammatory agent; Carbon-carbon lyases; Colorectal adenoma; Risk factor; Digestive diseases; Oxidoreductases; Single nucleotide polymorphism

Background: Previous research suggests that the G315A single-nucleotide polymorphism in the ornithine decarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk. Methods: We tested these hypotheses among participants...