Chronic heat stress affects muscle hypertrophy, muscle protein synthesis and uptake of amino acid in broilers via insulin like growth factor-mammalian target of rapamycin signal pathway

• Published in: Poultry science Vol. 97; no. 12; pp. 4150 - 4158
• Main Authors: Ma, Bingbing, He, Xiaofang, Lu, Zhuang, Zhang, Lin, Li, Jiaolong, Jiang, Yun, Zhou, Guanghong, Gao, Feng
• Format: Journal Article
• Language: English
• Published: England Poultry Science Association, Inc 01.12.2018
• Subjects: amino acids; Amino Acids - metabolism; Animals; aspartate transaminase; average daily gain; Avian Proteins - metabolism; blood serum; breast muscle; broiler chickens; Chickens; growth performance; heat; heat stress; Heat-Shock Response - physiology; hypertrophy; Hypertrophy - etiology; Hypertrophy - physiopathology; Hypertrophy - veterinary; insulin receptor substrate proteins; insulin-like growth factor I; Insulin-Like Growth Factor I - physiology; insulin-like growth factor I receptor; Male; males; messenger RNA; muscle development; Muscle Proteins - metabolism; muscle tissues; Muscular Diseases - etiology; Muscular Diseases - physiopathology; Muscular Diseases - veterinary; myogenin; Poultry Diseases - etiology; Poultry Diseases - physiopathology; protein synthesis; rapamycin; ribosomal proteins; Signal Transduction; solutes; temperature; TOR Serine-Threonine Kinases - physiology; uric acid; mTOR; chronic heat exposure; myogenic regulatory factor; amino acid transporter; broiler

ABSTRACT Heat stress markedly impairs the growth performance of broilers, such as the reduction of breast muscle mass and yield. The aim of this study was to examine the molecular mechanism of depressed muscle mass and yield caused by heat stress. A total of 144 (28-day-old) male broilers were alloc...