Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model - Savarino, Stephen J.; McKenzie, Robin; Tribble, David R.; Porter, Chad K.; O’Dowd, Aisling; Sincock, Stephanie A.; Poole, Steven T.; DeNearing, Barbara; Woods, Colleen M.; Kim, Hye; Grahek, Shannon L.; Brinkley, Carl; et al. (The Journal of infectious diseases, 2019)
Keywords: Adhesins, Bacterial - immunology; Adult; Animals; Antibodies; Antibodies, Bacterial - immunology; Bacterial Toxins - immunology; BACTERIAS; Cattle; Clinical trials; Colonization; Colostrum; Colostrum - immunology; Colostrum - microbiology; Developing countries; Diarrhea; Diarrhea - immunology; Diarrhea - microbiology; Double-Blind Method; E coli; Enterotoxigenic Escherichia coli - immunology; Enterotoxins - immunology; Escherichia coli; Escherichia coli Infections - immunology; Escherichia coli Infections - microbiology; Escherichia coli Proteins - immunology; Escherichia coli Vaccines - immunology; Female; Humans; Immunoglobulin G; Immunoglobulin G - immunology; Intestine; LDCs; Male; Prophylaxis; Protective Agents - pharmacology; randomized controlled clinical trial; milk proteins, immunology; controlled human infection model; diarrhea, prevention and control; Escherichia coli infections; bacterial vaccines; antibodies, bacterial; colonization factor antigens; fimbriae proteins; immunization, passive