METTL16 participates in haemoglobin H disease through m6A modification

• Published in: PloS one Vol. 19; no. 8; p. e0306043
• Main Authors: Liao, Yuping, Zhang, Feng, Yang, Fang, Huang, Shijin, Su, Sha, Tan, Xuemei, Zhong, Linlin, Deng, Lingjie, Pang, Lihong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2024; Public Library of Science (PLoS)
• Subjects: Anemia; Biology and Life Sciences; Blood; Blood diseases; Blood levels; Cell cycle; Correlation analysis; DNA microarrays; Epigenetics; Erythrocytes; Female; Flow cytometry; Gene expression; Genes; Genotype & phenotype; Growth factors; Hemin; Hemoglobin; Heterogeneity; Humans; Immunoprecipitation; Intracellular; Iron; Iron content; K562 Cells; Male; Medicine and Health Sciences; Methylation; Methyltransferase; Methyltransferases - genetics; Methyltransferases - metabolism; N6-methyladenosine; Patients; Peptides; Phenotypes; Physical Sciences; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Research and Analysis Methods; RNA, Messenger - genetics; RNA, Messenger - metabolism; siRNA; Synthesis; Transcriptomes; Tumorigenesis; Germany

Haemoglobin H (HbH) disease is caused by a disorder of α-globin synthesis, and it results in a wide range of clinical symptoms. M6A methylation modification may be one of the mechanisms of heterogeneity. Therefore, this article explored the role of methyltransferase like 16 (METTL16) in HbH disease....