Massive Release of CD9+ Microvesicles in Human Immunodeficiency Virus Infection, Regardless of Virologic Control

• Published in: The Journal of infectious diseases Vol. 225; no. 6; pp. 1040 - 1049
• Main Authors: Poveda, Eva, Tabernilla, Andrés, Fitzgerald, Wendy, Salgado-Barreira, Ángel, Grandal, Marta, Pérez, Alexandre, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, González-García, Juan, Bernardino, José Ignacio, Gutierrez, Félix, Fujioka, Hisashi, Crespo, Manuel, Ruiz-Mateos, Ezequiel, Margolis, Leonid, Lederman, Michael M, Freeman, Michael L
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.03.2022
• Subjects: Antiretroviral drugs; Antiretroviral therapy; CD9 antigen; Cell-Derived Microparticles; DNA, Mitochondrial; Extracellular Vesicles; Flow cytometry; HIV; HIV Infections; Human immunodeficiency virus; Humans; Immune system; Infections; Major and Brief Reports; Mitochondria; Mitochondrial DNA; Pathogenesis; Platelets; Polymerase chain reaction; Tetraspanin 29; Viremia; elite controllers; extracellular vesicles; microvesicles; HIV; mitochondria

Abstract Background The role of extracellular vesicles (EVs) in human immunodeficiency virus (HIV) pathogenesis is unknown. We examine the cellular origin of plasma microvesicles (MVs), a type of ectocytosis-derived EV, the presence of mitochondria in MVs, and their relationship to circulating cell-...