Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

• Published in: Journal of visualized experiments no. 140
• Main Author: McLaughlan, James R
• Format: Journal Article
• Language: English
• Published: United States MyJove Corporation 05.10.2018
• Subjects: Acoustics; Gold - chemistry; High-Energy Shock Waves; Humans; Lasers; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - chemistry; Neoplasms - diagnostic imaging; Neoplasms - therapy; Phantoms, Imaging; This Month in JoVE; Ultrasonic Therapy - instrumentation; Ultrasonic Therapy - methods; Ultrasonography - instrumentation; Ultrasonography - methods

In this study, plasmonic gold nanoparticles were simultaneously exposed to pulsed near-infrared laser light and high intensity focused ultrasound (HIFU) for the controllable nucleation of cavitation in tissue-mimicking gel phantoms. This in vitro protocol was developed to demonstrate the feasibility...