Determination of bosutinib in mice plasma and tissue by UPLC-MS/MS and its application to the pharmacokinetic and tissue distribution study

• Published in: Analytical methods Vol. 7; no. 21; pp. 9184 - 9189
• Main Authors: Wang, Linxia, Tang, Luming, Zheng, Yi, Pan, Guoquan, Zhu, Wei, Pan, Chenwei, Zhu, Lihe
• Format: Journal Article
• Language: English
• Published: 01.01.2015
• Subjects: Acetonitrile; diazepam; formic acid; ionization; Mass spectrometers; Mathematical analysis; Mice; Monitoring; oral administration; pharmacokinetics; Precipitation; Quadrupoles; spectrometers; tandem mass spectrometry; tissue distribution; ultra-performance liquid chromatography

A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine bosutinib in mice plasma and tissue using diazepam as the internal standard (IS). Sample preparation was accomplished through a protein precipitation procedure with a...