Beyond the tail: the consequence of context in histone post-translational modification and chromatin research

• Published in: Biochemical journal Vol. 481; no. 4; p. 219
• Main Authors: Weinzapfel, Ellen N, Fedder-Semmes, Karlie N, Sun, Zu-Wen, Keogh, Michael-Christopher
• Format: Journal Article
• Language: English
• Published: England 21.02.2024
• Subjects: Chromatin - genetics; Histones - metabolism; Nucleosomes - genetics; Protein Processing, Post-Translational; nucleosome; histone peptides; histone post-translational modifications; histone code; histones; chromatin

The role of histone post-translational modifications (PTMs) in chromatin structure and genome function has been the subject of intense debate for more than 60 years. Though complex, the discourse can be summarized in two distinct - and deceptively simple - questions: What is the function of histone...