In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

• Published in: The Journal of experimental medicine Vol. 205; no. 12; pp. 2887 - 2898
• Main Authors: Meiler, Flurina, Zumkehr, Judith, Klunker, Sven, Rückert, Beate, Akdis, Cezmi A., Akdis, Mübeccel
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 24.11.2008
• Subjects: Adult; Aged; Allergens - administration & dosage; Allergens - immunology; Animals; Bee Venoms - administration & dosage; Bee Venoms - immunology; Bees; Cytokines - blood; Cytokines - genetics; Cytokines - immunology; Female; Humans; Immune Tolerance - physiology; Interleukin-10 - secretion; Male; Middle Aged; Occupational Exposure; Occupations; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Receptors, Histamine - genetics; Receptors, Histamine - immunology; Seasons; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - secretion

High dose bee venom exposure in beekeepers by natural bee stings represents a model to understand mechanisms of T cell tolerance to allergens in healthy individuals. Continuous exposure of nonallergic beekeepers to high doses of bee venom antigens induces diminished T cell–related cutaneous late-pha...