Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing

• Published in: Chemico-biological interactions Vol. 172; no. 3; pp. 206 - 215
• Main Authors: Nioi, Paul, Pardo, Ingrid D.R., Sherratt, Philip J., Snyder, Ronald D.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 15.04.2008
• Subjects: 2-Year bioassay; Animals; Biological Assay - methods; Biomarkers - analysis; Carcinogenicity Tests; Carcinogens - toxicity; Dose-Response Relationship, Drug; Gene expression changes; Gene Expression Regulation, Neoplastic - genetics; Gene signature; Male; Non-genotoxic carcinogenesis; Polymerase Chain Reaction; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Risk Assessment; Short-term dosing; Time Factors; Gene expression changes; Gene signature; Short-term dosing; 2-Year bioassay; Non-genotoxic carcinogenesis

Non-genotoxic carcinogenicity of chemicals is currently routinely evaluated in 2-year rodent bioassays. Therefore, the development of early biomarkers for non-genotoxic carcinogenesis would result in substantial savings in time and expense. The current study investigates whether early changes in gen...