Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine‐resistant human pancreatic cancer cells

• Published in: Phytotherapy research Vol. 34; no. 8; pp. 2053 - 2066
• Main Authors: Lin, Ji‐Hua, Chen, Sheng‐Yi, Lu, Chi‐Cheng, Lin, Jer‐An, Yen, Gow‐Chin
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2020; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma; advanced glycation end products; Advanced glycosylation end products; Antifungal agents; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; apple peels; Autophagy; Cell culture; Cell cycle; cell cycle checkpoints; Cell death; Cell Line, Tumor; cell lines; Cell Proliferation; Cell viability; Cytotoxicity; dose response; drugs; Endoplasmic reticulum; Gemcitabine; gemcitabine resistance; Glycosylation; Humans; methodology; neoplasm cells; Pancreatic cancer; pancreatic neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - mortality; Phagocytosis; phytotherapy; Product safety; RAGE; rosemary; Survival Rate; thyme; Toxicity; Triterpenes - pharmacology; Triterpenes - therapeutic use; Ursolic Acid; apoptosis; pancreatic cancer; autophagy; RAGE; gemcitabine resistance; ursolic acid

Gemcitabine (GEM) resistance in pancreatic adenocarcinoma mediated by the receptor for advanced glycation end products (RAGE) has been demonstrated. Therefore, investigating the safety and the potential of new auxiliary methods for pancreatic cancer treatment is urgent. Ursolic acid (UA), a natural...